The diverse roles of DNA methylation in mammalian development and disease

MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
… somatic cell development. Finally, we provide insights into DNA methylation gained from …
insights gained into the patterning of DNA methylation during development. Finally, we discuss …

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

AE Jaffe, Y Gao, A Deep-Soboslay, R Tao… - Nature …, 2016 - nature.com
development in the human brain than was previously available. Although previous efforts
to comprehensively measure DNA methylation … features of brain development 16 , our study …

Vitamin D and its effects on DNA methylation in development, aging, and disease

LTC Ong, DR Booth, GP Parnell - Molecular Nutrition & Food …, 2020 - Wiley Online Library
… vitamin D and DNA methylation in candidate … on DNA methylation. In light of current knowledge
in the field, the potential mechanisms mediating vitamin D effects on DNA methylation are …

DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes

Z Chen, F Miao, BH Braffett, JM Lachin, L Zhang… - Nature …, 2020 - nature.com
… Here, we show the involvement of epigenetic DNA methylation (DNAme) in metabolic … , and
with subsequent development of complications over an 18-yr period in the blood DNA of 499 …

DNA methylation homeostasis in human and mouse development

M Iurlaro, F von Meyenn, W Reik - … opinion in genetics & development, 2017 - Elsevier
The molecular pathways that regulate gain and loss of DNA methylation during mammalian
development need to be tightly balanced to maintain a physiological equilibrium. Here we …

DNA methylation reprogramming during mammalian development

Y Zeng, T Chen - Genes, 2019 - mdpi.com
… , are usually devoid of methylation [2]. DNA methylation is essential for mammalian development
and is involved in … Aberrant DNA methylation patterns and mutations of genes encoding …

Sex-specific programming of cardiac DNA methylation by developmental phthalate exposure

LK Svoboda, K Wang, RG Cavalcante… - Epigenetics …, 2020 - journals.sagepub.com
… To determine the effect of perinatal DEHP exposure on cardiac DNA methylation in offspring
mice, we performed enhanced reduced representation bisulfate sequencing on DNA from …

[HTML][HTML] DNA methylation and DNA methyltransferases

JR Edwards, O Yarychkivska… - Epigenetics & …, 2017 - epigeneticsandchromatin …
… of the shape of genomic methylation patterns and the nature … development. We observe
that the sequences that undergo deep changes in methylation status during early development

Transgenerational sperm DNA methylation epimutation developmental origins following ancestral vinclozolin exposure

MK Skinner, E Nilsson, I Sadler-Riggleman, D Beck… - Epigenetics, 2019 - Taylor & Francis
… variation in DNA methylation at this stage of development. … DNA methylation alterations for
the different developmental … had distinct patterns of DNA methylation compared to the other …

[HTML][HTML] DNA methylation in development and disease: an overview for prostate researchers

DB Joseph, DW Strand, CM Vezina - American journal of clinical …, 2018 - ncbi.nlm.nih.gov
… the DNA methylation machinery. More specifically, we describe DNA methylation in the context
of prostate development, … and environmental factors on DNA methylation in the prostate. …